Fuchs endothelial dystrophy (FED) of the cornea is slowly progressive degenerative disorder of the cornea which is characterized by death of corneal endothelial cells, ie. the cells maintaining the transparency of the corneal tissue. Unfortunately, the loss of endothelial cells is permanent and progressive because they do not have the possibility of renewal and regeneration. The disease can be inherited as an autosomal dominant disease, although in most cases is sporadic, but also what is important are genetic and environmental predisposing factors such as older age and female sex.
Loss of endothelial cells can also be induced by trauma or intraocular operations such as. cataract surgery. Although you can see the early signs of the disease in people in their 30s and 40s, the disease rarely causes visual impairment before the 50's or 60's.